从事设计工作的单身妈妈蔡闵英带着6岁的女儿珠熙搬入某商品房的504室,由于迷信,所谓5楼就是4楼而已。大厦安静舒适,正适合闵英这样经常夜间工作的人。母女俩生活简单有序,波澜不惊。然而好景不长,奇怪的响动搅扰了母女的生活。3楼的单身男子韩昌洙抱怨母子二人过于吵闹,一向喜好安静的闵英对此倍感诧异,在她看来那吵闹声正是来自于楼下。不久,一个放高利贷的男子惨死电梯间,接着经常在家独处的珠熙举止也变得愈加孤僻和诡异。
闵英的不安与日俱增,她隐约感到这栋大厦和所住的房间有些问题。但当她想逃离时,却发现事情并非如此简单……。山田日後承認在開拍此片之前,已心諳渥美清的肺病步入末期,決定此章為最後一章,並安排由淺丘瑠璃子演的莉莉送寅次郎踏上人生的最後一程。分別15年後,兩人於如詩如畫的奄美大島重逢,感情依舊,鬥氣繼續,沒完沒了似的。正如山田所想,雖然系列必須完結,但始終不想為寅次郎的故事/人生劃上句號。結局如常開放,代表寅一直繼續他的旅程,日本人依然有夢。
公映後翌年,渥美清病逝,享年68歲,本片亦成為他的遺作。
Yamada knew before production began that Atsumi's health has deteriorated to such an extent that Tora-san to the Rescue would be the last film in the series. He decided to let Lily accompany Tora on his last trip. The lovers reunite after fifteen years in the picturesque Amami O Shima, and the affections as well as the bickering remain. Although the series must come to its conclusion, Yamada has deliberately left the film's ending open, so as not to let the curtain fall on "Tora-san". Atsumi Kiyosh passed away at the age of 68 in the year following the film's release, making this film his last.。